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Many experiencing nausea describe it as mild background queasiness rather than debilitating sickness

Most large-scale trials have had relatively short follow-up periods (typically 2 to 4 years), and the sustained efficacy of these therapies beyond this timeframe has not been fully established

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Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)

A 26-week, multicenter, double-blind trial assessed the efficacy and safety of once-daily semaglutide compared to once-daily liraglutide and placebo in patients with type 2 diabetes

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