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[42] pooled 31 long-duration RCTs (84,713 participants) of GLP-1 RAs in diabetes and obesity, populations again largely free of significant psychiatric comorbidity, and found no increase in depression, anxiety, or suicidality, providing robust evidence for psychiatric safety in large, controlled settings

The glycine addition generally does not change the patient experience but may extend shelf life and maintain potency across the storage period

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