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This SC layer forms the principal barrier to drug permeation, largely due to its unique lipid composition, predominantly ceramides, cholesterol, fatty acids, and cholesteryl sulfate, arranged in bilayer structures within intercellular spaces [48, 223,224,225]

Oh, gosh, things could go bad

Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation

Topical application in women with photodamaged skin showed a significant reduction in lines and wrinkles as well as improved skin thickness compared to the placebo and Vitamin K cream after 12 weeks of application

And the results are really fascinating

Epub 2010 Mar 10