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A comprehensive understanding of these diverse metabolic programs is essential for developing precision therapies aimed at disrupting CSC survival

While SARS-CoV-2 variants appear to occur sporadically in different geographical locations across the globe, they do not culminate in more severe diseases than the ancestral strain, albeit altered virus virulence, pathogenesis, and transmissibility have been documented

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Recently, oleuropein, a polyphenol, was shown to have the senolytic potential in OA chondrocytes ( in vitro expansion requires additional study

Aging 2020;12:152819

- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)