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NNMT inhibition reduces consumption of nicotinamide (and of S-adenosylmethionine) by blocking the enzyme that would otherwise methylate them
It also facilitates the release of growth hormone, insulin, glucagon, and prolactin, important hormones for metabolic drive
List JF, He H, Habener JF
Adipose tissue GLP-1 agonists like semaglutide may minimize the reduction of leptin production by fat tissue, which typically occurs during fat loss
Available from: Drucker DJ (2018) Mechanisms of action and therapeutic application of glucagon-like Peptide-1
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