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doi: 10.1093/oxfordjournals.aje.a010122 52 XiongSSharkeyAMKennedyPRGardnerLFarrellLEChazaraOet al

While many of these molecules showed promising results in preclinical rodent, minipig, or non-human primate (NHP) models, they could not achieve sufficient therapeutic windows to observe clinical weight loss without adverse events such as cardiac activation ( MK-0493 MK-0493 is an orally available small molecule developed by Merck ( Figure 2 )

J Autism Dev Disord (2008) 38:11707.10.1007/s10803-007-0492-z 93 RamaekersVTSequeiraJMBlauNQuadrosEV

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Then, serine hydroxymethyltransferase converts serine into glycine, which will enter one-carbon metabolism

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