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In preclinical models using intragastric administration, researchers observed effects comparable to parenteral routes for gastrointestinal endpoints
These effects are typically mild, resolve within hours to days, and don't require treatment
[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe
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