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AMPK activation promotes 2,3-bisphosphoglycerate (2,3-BPG) synthesis by stimulating bisphosphoglycerate mutase (BPGM) and phosphorylating phosphoglycerate mutase (PGAM), accelerating the conversion of 3-phosphoglycerate to 2-phosphoglycerate

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Strategy: Structured Refeeds Periodic higher calorie days, particularly with increased carbohydrate intake, temporarily boost metabolic hormones like leptin and thyroid hormone T3

These insignificant changes may be attributed to bias caused by the small sample size of the included studies

Study of insulin resistance in relation to serum IGF-I levels in subjects with different degrees of glucose tolerance