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Here, we present cryo-electron microscopy structures showing that GLP-1(9-36) binds to an atypical site composed of the upper halves of transmembrane helices 1 (TM1) and 2 (TM2), extracellular loop 1, and the extracellular domain, distinct from the binding site of GLP-1(7-36)

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Autoimmune thyroid disorders Hashimotos thyroiditis Hashimoto thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas, and it is caused by thyroid gland destruction due to autoimmune disturbance, where the thyroid follicular cells are subjected to death by the effect of CD8 + T cells