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Hence, it is not clear how this S-CH 3 -APAP metabolite could contribute to the analgesic effects when produced in large quantities in humans

Pyroptosis: palmitoylation regulates GSDMD activation and pore formation

Iwai S, Sueki H, Watanabe H, Sasaki Y, Suzuki T, Iijima M

Generally safe

The authors have no relevant financial or non-financial interests to disclose

Overall, experience from the oncology field suggests that amino acid metabolism intervention is more likely to be implemented through well-defined clinical development strategies, including monotherapy or combination therapy, dose escalation, safety monitoring, and immune pharmacodynamic endpoints, and may provide a useful framework for trial design and stratification in immune-mediated diseases