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Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

While ASOs are primarily used to treat neurological and metabolic disorders, their role in cancer therapy is expanding, especially following the FDA approval of imetelstat for specific myelodysplastic syndromes

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Scientific literature showed clearly how effective exercise could be in preventing, and even treating, chronic disease

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

In our study, patients with serum albumin levels below 2 g/dl and above 5.5 g/dl will be excluded so that IMA levels are not affected by low and high albumin levels