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One large study, called the SUSTAIN-6 trial, looked at people with type 2 diabetes who had a high risk of heart disease

Their A1c decreased from 7.1% in June 2024 to 6.0% by December 2025

Direct stimulation of GLP-1R on cardiomyocytes increases cAMP and activates the PI3K/Akt pathway, thereby improving contractility and reducing apoptosis, which preserves left ventricular function and cardiac output (47)

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It is whether a qualified clinician obtained enough information to decide that the medication is appropriate, prescribed a reliable product, and remained available to manage what happens next

We believe that GLP-1 and BMS21 share the same binding site in the GLP-1R TM domain given their high sequence identity (7 identical of out 11 residues)