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We elucidated previously unnoted ways in which GLP-1RAs curbed RA pathology via direct suppression of the cGAS-STING signaling pathway to inhibit chondrocyte ferroptosis and concomitantly induced macrophage M2 polarization

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Even small amounts can continue to trigger the immune response

In summary, the GSH-GSSG redox cycle does not exist in isolation, but rather operates as a dynamic equilibrium system that is highly coupled to the NADPH metabolic network