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Upon receptor binding, IGF1R undergoes autophosphorylation, initiating downstream signaling pathways, including: Phosphoinositide 3-kinase (PI3K)/Akt pathway Mitogen-activated protein kinase (MAPK) pathway These pathways are associated with intracellular signal transduction processes, including regulation of gene expression, protein translation, and cellular signaling dynamics at the molecular level

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They found that oral administration of EPA-E inhibited the reduction of thyroid hormone levels and the change of thyroid follicles in the hypothyroid rats, suggesting that n-3 PUFA may prevent methimazole-induced hypothyroidism