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In addition to protecting macrophages from free cholesterol overload, activation of PPAR and LXR promotes the transcriptional regulation of efferocytic receptors, such as MerTK, and opsonins, including MFG-E8 and Gas6 [66]

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Clinical trials show tirzepatide produces approximately 3-5% additional body weight loss compared to semaglutide in head-to-head studies, with the largest benefit in patients with lower baseline GLP-1 receptor sensitivity

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For a detailed breakdown of its structure and laboratory handling, see Sempicas guide on how to reconstitute tirzepatide 30mg