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Vital bodily functions can be impacted when glutathione levels are too low

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Diarrhea : Some patients experience loose stools or frequent bowel movements, particularly when starting the medication

Clinical trials demonstrate continued weight loss with dose escalation, and many patients benefit from titration to 10 mg or 15 mg weekly if tolerability permits

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While the top of TM6 and ECL3 could not be confidently modelled for the exendin-4 complex, the portion of TM6 and TM7 that were modelled, along with the weak density corresponding to ECL3 supports a backbone conformation more similar to GLP-1 and oxyntomodulin bound receptors, rather than exendin-P5, albeit it is likely that this region is more conformationally dynamic