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In the synthesis method of cagrilinteide, the coupling reaction specifically comprises: weighing 5.71g of Rink AmideAM resin (the resin substitution degree is 0.35mmol/g) and adding into a solid phase reactor, and adding 50mL of DCM to swell the resin for 0.5 h

Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling

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In the SURPASS-2 study, tirzepatide 15 mg resulted in a faster and greater decline in body weight ( 5.5 kg) compared to semaglutide 1.0 mg, more than doubling the proportion of patients achieving at least 10% weight loss (57% vs 24%) [3]

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