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Buglio D, Konopleva M, McQueen T, Samudio I, Broglio KR, Ruvolo V, Contractor R, Chen W, Kantarjian H, Andreeff M , Weiser MA

This happens for two main reasons: 1

This design constraint reduced the impact of polar and charged groups, enabling a focused examination of how molecular size affects permeability

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Wang Y, Xiao T, Zhang Z, Feng X (2021) Extraction and concentration of glutathione from yeast by membranes

2 For a 505(b)(2) sponsor, these new indications represent a value continuum where they can repurpose an established molecule for a specialized population with much lower risk