Michael Colgan, warned decades ago that even a small drop in body water is enough to sabotage physical performanceand that is well before thirst even kicks in
High rates of attrition (12%) were observed in Altimmunes trials, and 5% of patients on semaglutide discontinued treatment due to nausea, vomiting or diarrhea (with 25-44% of patients reporting symptoms)
The most common ones are usually mild and improve over time: Nausea (especially when starting) Diarrhea or constipation Decreased appetite Fatigue during adjustment period Stomach discomfort Serious But Rare Side Effects More serious side effects are uncommon but require medical attention: Severe allergic reactions Pancreatitis (inflammation of the pancreas) Gallbladder problems Low blood sugar (if combined with diabetes medications) Kidney problems Sleep-Related Considerations Some people report temporary sleep changes when starting GLP-1 medications: Initial insomnia or restlessness (usually improves) Changes in dream patterns Temporary fatigue as body adjusts Mood changes that can affect sleep Most sleep-related side effects resolve within a few weeks as your body adapts to the medication
Serena Williams Flaunts Her 35-Lb Weight Loss While Dancing At Cardi B's Atlanta Show Serena Williams recently shared a video of herself dancing at a Cardi B concert in Atlanta, showcasing her weight loss and impressive moves
Excess body fat, particularly around the abdomen, increases insulin resistance
The FDA decision is anticipated in 4Q 2025
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