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Pre-clinical tests can last years

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Early human studies demonstrated modest weight loss and appetite suppression, but development was curtailed due to concerns regarding glucagon-mediated hyperglycemia and cardiovascular effects

In the course of ferroptosis, acyl-CoA synthetase long-chain family member 4 (ACSL4), lysophosphatidylcholine acyltransferase 3 (LPCAT3), and lipoxygenases (LOs) are the key drivers in the formation of oxidized PUFAs ( Figure 6 )