Alzheimers disease and Helicobacter pylori infection: Inflammation from stomach to brain
Zinsmeyer, K
Cht kem mn, d dng thm thu vo da, khng b l chn lng hoc lm gy mn
Chronic oral inflammation correlates with insulin resistance and neurodegeneration
First, using germ-free animals, directional microbiota transplantation, and gene editing techniques to clarify the causal mechanisms by which protective genera such as Bifidobacterium regulate the hepcidin-FPN1 axis and key molecules of chondrocyte ferroptosis (GPX4, SLC7A11), thereby consolidating the logical chain of microbiota-iron metabolism-cell death. Second, leveraging longitudinal cohorts and multi-omics technologies to reveal the time-dependent evolution of the gut dysbiosis-iron overload-ferroptosis-intestinal dysfunction cycle and identify key windows for early intervention
Because of its dual role in cellular energy production and antioxidant defense, CoQ10 contributes to maintaining overall vitality, skin health, and normal physiological function
