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The other just delivered 28.7% body weight reduction in Phase 3 trials, numbers that rewrote what researchers thought was possible

Abstract The introduction of the highly potent incretin receptor agonists semaglutide and tirzepatide has marked a new era in the treatment of type 2 diabetes and obesity

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Discontinuation due to side effects was slightly higher at the higher doses, up to 5.1%

Both incorporate glucagon receptor agonism alongside GLP-1 activity, but retatrutide takes this further by adding a third target -- GIP receptor agonism -- making it the first triple-hormone receptor agonist in clinical development

These multi-dimensional benefits suggest that retatrutide is more than a weight-loss drug