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Controlled freezing studies of recombinant hGH demonstrated that insoluble particulate aggregation increases sharply with cooling rate, with pH 7.4 formulations producing markedly more light-scattering particulates than pH 7.8 formulations after freeze-thaw (Eckhardt, Oeswein & Bewley, 1991)

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As a secondary goal, we explored the functional effects of NPW (indexed by relative cerebral blood flow, rCBF) on the pituitary (related to stress and HPA stimulation) [15, 19] and habenula (implicated in NAL aversion) [20]

But it may continue in the chronic stage