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The mechanisms observed in controlled laboratory settings may not fully translate to real-world clinical outcomes, and the durability of any effect remains uncertain

The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy

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Glutathione is considered an anti-ager used by the body to defend against free radical damage and is found in high amounts in the liver

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However, clinical evidence on actual plasma glutathione elevation remains limited