A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)
I will say there are a lot of anecdotal reports about initial insomnia and elevated heart rate (presumably lowered HRV) on the forums, and I did experience that when starting tirzepatide and when trying retatrutide, but the insomnia and heart rate issues seemed transient
Vitamin B12 is a nutrient that plays an essential role in multiple bodily functions, including red blood cell production and neurological function
GLP-1 receptor agonist medications are designed to mimic certain actions of this hormone
van der Wel T
When stomach emptying slows significantly, the timing and amount of hormone absorption may shift, potentially affecting contraceptive efficacy