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Escalating too quickly increases nausea, reflux, and discontinuation risk

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Research shows that a significant proportion of weight lost on GLP-1 medications can come from lean mass, with estimates suggesting up to 3040% of total weight loss may be muscle and bone density, rather than fat (Neeland et al

Genetic variation in GLP-1 receptor signaling, GIP pathway sensitivity, and metabolic efficiency influences both therapeutic response and adverse reaction intensity

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Side effects are often easier to manage with a gradual, supportive approach: Eat smaller meals and slow down when eating