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The results could have differed had patients started treatment sooner to optimize their response

Despite recent developments in the field of metal-based catalytic drugs, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses 29

Target: Up to 1,000 mcg (1.0 mg) daily by Weeks 910+ if well tolerated [7]

Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma