The most meaningful results appear at the one-to-two year mark, not in the first few weeks
Regarding this, GLP-1RAs inhibit ER stress and promote protein folding via endoplasmic reticulum oxidoreductase (ERO1) in an AMPK-dependent manner, as well as mediating the process of mitochondrial fusion [115, 151]
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While your body's natural GLP-1 has a short lifespan of just 2 to 3 minutes before being broken down, it performs essential metabolic functions that help maintain glucose homeostasis
