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Initially adaptive, this hyperfiltration response compensates for declining nephron mass but eventually exacerbates glomerular damage

Phase 2 weight loss (48 weeks): 17.1% at 4 mg maintenance 8 mg Weeks 912 Strong therapeutic dose with substantial appetite suppression and metabolic improvements

Six hours after transfection, medium was switched to medium containing 5% FBS for 24 h

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Using multi-dimensional cluster analysis, the authors showed that putatively resistant individuals mounted a distinct and robust IgG1 response to a small set of newly discovered and well characterized surface tegument antigens compared to chronically infected individuals who mounted strong IgE and IgG4 responses to many antigens (178)