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Thyroid considerations: In animal studies, GLP-1 receptor agonists have been associated with thyroid C-cell tumours, though relevance to humans remains uncertain

Patients achieving a reduction from baseline of at least 10%, 15%, and 20% were confirmatory secondary outcomes in the STEP 1 to STEP 3 studies, and the differences between semaglutide and placebo were statistically significant at each of these thresholds, across all of the studies (Table 23)

- 11% higher risk of arthritis: this finding contradicts earlier studies suggesting weight loss from these drugs could alleviate joint pain

Results showed that BN could reduce glucose levels, improve insulin secretion in glucose tolerance tests in a dose-dependent manner, and inhibit food intake and gastric emptying

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