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The chemistry behind the rule

546 Beyond lipid-lowering therapies, there are positive developments in other areas of NADs application

Olaparib, for instance, is an FDA-approved inhibitor of the enzyme poly ADP ribose polymerase (PARP) which can efficiently kill BRCA mutant tumor cells, a successful synthetic lethality based targeting strategy used in breast cancers and ovarian cancers (165)

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This could be because injections provide a more direct systemic effect compared to oral administration, which might target gut-specific conditions more effectively 1