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While off-label prescribing is legally permissible in the US, it should be approached with caution, informed consent, and appropriate monitoring when considering these medications for patients with problematic alcohol use

Dardano A, Bianchi C, Garofolo M, Del Prato S

Treatment recommendations are individualized and based on safety, appropriateness, and clinical judgment

The researchers also observed that 532 participants with BMI 35 at week 0, who had tolerated their assigned dose of medication, were then escalated to the maximum tolerated dose (9mg or 12mg) for a further 24 weeks

GLP-1 in higher amounts also interacts with the parts of the brain that reduce appetite and signal a feeling of fullness.

Many patients transition to a lower maintenance dose over time