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THP-1 cells were seeded at 2 10 5 cells per well in complete RPMI 1640 medium with 100 nM phorbol 12-myristate 13-acetate (PMA) (Cayman) and differentiated into macrophages for 3 days, then rested in PMA-free medium for 16 h before infection

Pentose phosphate pathway The pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt or HMP shunt ) is a metabolic pathway parallel to glycolysis

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MHC, major histocompatibility complex

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Although obesity is increasingly recognized as a chronic disease, these data suggest that many still consider it a lifestyle condition