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Currently, a body of clinical trials addressing the interventional impacts of statins alone or with non-immunotherapy treatment in HCC have been initiated (Table 2)

Negligible side effects emerged

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Peptide therapy may not be recommended for individuals with active or recent cancer, pregnant or breastfeeding women, people with known copper metabolism disorders, severe uncontrolled medical conditions, or those seeking unsupervised self-administration

A recent study of BBB penetration by GLP-1 class drugs on the market and dual agonists that have modifications to cross the BBB at an enhanced rate confirmed this (Salameh et al., 2020)

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