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Regarding the participants with MCI or AD, defined based on a clinical dementia rating (CDR) global score of 0.5 or 1, although the 18-month treatment with exenatide was safe and well-tolerated, it did not significantly affect clinical and cognitive measures, nor did it affect MRI cortical thickness and volume or most biomarkers in the cerebrospinal fluid (CSF), plasma, and plasma neuronal extracellular vesicles (EVs)

It notes that response varies between individuals because of differences in metabolism and gut sensitivity, so some people reach the intended effect at lower amounts while others need more

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2A) and the GSH/GSSG ratio (t = 2.141, p = 0.034, Cohens d = 0.31, Fig