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Moreover, given that there are now millions of patient-years of clinical experience with DPP-4 inhibitors since they were given regulatory approval in 2006, their benign, placebo-like side effect profile (39) also suggests that the number of physiologically relevant substrates is likely to be limited

Serum insulin levels were also increased without a corresponding change in glucose levels

However, evidence suggests that other mechanisms continue to support efficacy

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It was when I combined my HRT (Hormone Replacement Therapy) and a GLP-1, like Semaglutide that I was finally able to shed that last 15 pounds