When energy intake drops sharply and fat stores deplete rapidly, the hypothalamic-pituitary axis responds by downregulating processes deemed non-essential for survival
Thus, the results of earlier studies [16, 18, 19], which have relied on exendin(939)amide being specific for only the GLP-1 receptor, should be interpreted with caution, especially with respect to the relative contribution of GLP-1 to the enteroinsular axis
When mitochondria cannot efficiently process fatty acids for energy, those fats accumulate contributing to the metabolic sluggishness, fatigue, and weight resistance that many women with PCOS experience
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