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Translational in vivo and in vitro studies in patient (pts) with acute myeloid leukemia (AML), chronic myeloid leukemia (CML) and myeloproliferative disease (MPD) treated with MK-0457 (MK), a novel Aurora kinase, Flt3, JAK2, and Bcr-Abl inhibitor

Onset by formulation (approximate, from prescribing information): Ritalin IR: 20 to 30 minutes Adderall IR: 30 to 60 minutes Adderall XR: 30 to 60 minutes Concerta / Ritalin LA: 30 to 60 minutes Vyvanse: 60 to 120 minutes Duration by formulation (approximate, from prescribing information): Ritalin IR: 3 to 5 hours Adderall IR: 4 to 6 hours Ritalin LA: 6 to 8 hours Adderall XR: 8 to 12 hours Concerta: 8 to 12 hours Vyvanse: 10 to 14 hours How long does vyvanse last compared to the others