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The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia

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Outcomes The primary outcome was the measurement of total testosterone levels before and after GLP-1 RAs administration, chosen for its strong association with the clinical manifestations of hypogonadism in men

Quick Answer: Semaglutide has been studied for over 14 years, with clinical trials beginning in the early 2010s and approximately 7 years of real-world post-marketing experience since FDA approval in December 2017