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This reaction might be more pronounced in some patients due to their individual immune system characteristics

CCL11 is highly expressed in SMC-rich area of the atherosclerosis plaque and injured arteries, suggesting that it plays an important role in regulating SMC migration [40, 41]

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While dose adjustment is not always necessary, altered metabolic states may influence drug response and tolerability

ACE (Angiotensin I converting enzyme), which converts angiotensin I to angiotensin II, is involved in blood pressure regulation 53 and has shown roles in intestinal homeostasis, including terminal digestion of peptides 49 , cell turnover 54 and glucose uptake inhibition via local production of angiotensin II 55

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