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Design of Disulfide Linkers Conjugation makes use of the sulfhydryl group of cysteines (mAb-SH) on monoclonal antibody to undergo a S N 2 type reaction with the disulfide bond on the linker [1] to generate the target ADC (Figure 1, product A )

These situations include nasal congestion and blockage, nasal discharge, atrophy of nasal mucosa, and severe atrophic rhinitis

M.DanielK.et al

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Agreement on clinically relevant outcome measures is also lacking,71 and many studies have clear conflicts of interest

Abrahams, W