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Tirzepatide has less breast milk excretion data than semaglutide

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GLP-1 (glucagon-like peptide-1) receptor agonists, such as Semaglutide , are a class of medications originally developed for the treatment of type 2 diabetes but have also gained recognition for their role in weight management

I believe it relates to health of vagal afferent signaling and GLP-1 resistance

JAMA 331 , 3848 (2024)

Network meta-analyses suggest that higher-dose semaglutide (1 mg and 2 mg weekly) and tirzepatide (a dual GIP/GLP-1 receptor agonist) demonstrate superior A1c reductions compared to other agents in the class, with mean reductions of 1.52.0% or greater from baseline