Lillys Retatrutide: Toward the End of Incremental Metabolic Medicine Why GLP-1++ therapies are redefining what is worth developing and what is not In early December 2025, Eli Lilly announced landmark Phase 3 results for retatrutide its investigational once-weekly triple hormone receptor agonist targeting GLP-1, GIP, and glucagon
Berberine, Currently taking Why
Severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) was not reported in any of the patients receiving semaglutide monotherapy compared to 1.6% of patients receiving placebo
Side effects, including fatigue, tend to peak during this escalation phase and typically improve once you reach your maintenance dose
your surgical team can modify offending medications and recommend topical fluoride to prevent decay
Leah Joseph, MD, FACP , provides expert guidance to help you choose the best treatment for your needs