Regarding the hippocampus, both ER and ER have been observed in hippocampal NSPCs of human post-mortem samples and a human hippocampal progenitor cell line (Smeeth et al., 2020)
doi: 10.1007/s40618-021-01600-w 55 WalshJPWardLCBurkeVBhagatCIShielsLHenleyDet al
Interestingly, such signs of mitochondrial dysfunction have also been described in MDD and long COVID: de Boer et al
doi:10.3389/fendo.2021.645563
Increasing the intake of nutrients such as fiber, protein and exercise will do exactly the same while feeding your gut microbiome, stabilizing your hormones and blood sugar and mental health, while increasing your muscle mass naturally
Over-the-counter options such as meclizine for nausea or loperamide for diarrhea can help, but check with your clinician before starting any new medicine, especially if you take other prescriptions