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The reason for this is that there is skewing of X chromosome inactivation such that females with one mutant PDHA1 gene appear to have the X chromosome harboring the wild-type PDHA1 gene inactivated at a higher rate than predicted based upon the normal random X-inactivation process

2019 Annual Report of the American Association of Poison Control Centers National Poison Data System (NPDS): 37th Annual Report

The correct calculation requires converting 2.5mg/mL to 2500mcg/mL first, yielding 250mcg 2500mcg/mL = 0.1mL