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Schenck, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States This article was submitted to Structural Biology, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

CGRP released from cutaneous trigeminal nerve fibers and acts on surrounding Schwann cells, perpetuating cutaneous allodynia through a cyclic AMP-dependent mechanism that generates NO in endosomes (31)

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The risk of B12 deficiency is particularly relevant for patients following plant-based diets, those with existing digestive disorders, or individuals with genetic variants affecting nutrient absorption pathways

Another important aspect is managing stress , as high stress levels have been linked to various skin issues, including melasma