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The crystal was directly mounted without any cryoprotectants

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Its essentially how we got from willow bark to aspirin, or from Gila monster venom to GLP-1 weight loss drugs

In addition, cotreatment of docetaxel-resistant NSCLC with docetaxel plus R162 inhibited cancer cell growth and metastasis both in vitro and in xenograft mouse models, again suggesting that combination therapy with anticancer drugs plus a GLUD1 inhibitor is an effective cancer treatment 23

No impact on the LC-HRMS/MS identification of the analytes was observed, and the methods robustness was demonstrated