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Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome

Notably, KI did not affect the expression levels of genes encoding lipoxygenases ( Alox5 and Alox15 ) or glutathione peroxidase ( Gpx4 ) (Figure S6C)

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However, if reclassification does occur, it may create both opportunity and operational strain across clinical programs, pharmacy networks, compliance infrastructure, and financial models