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63 Furthermore, BCAT 1 is selectively upregulated in isocitrate dehydrogenase (IDH) wild-type (WT) GBM, and -ketoglutarate (-KG) mediates cell death in BCAT 1-deficient IDH WT GBM

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The original STEP UP trial, published in The Lancet in November 2025, showed that patients taking the higher 7.2 mg dose lost an average of 20.7% of their body weight

Glutathione is present throughout the lower respiratory tract and is considered a firstline antioxidant defense

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