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Patients should be counseled on strategies to minimize these effects, including eating smaller meals, avoiding high-fat foods, and maintaining adequate hydration

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After losing a kidney to renal cell carcinoma, her GFR dropped to stage 3 chronic kidney disease (CKD)

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This makes annual cost predictable, removes the financial incentive to stay at sub-optimal doses, and aligns the financial structure with clinical best practice (titrate to effective dose)

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